MicroRNA, or miRNA, are small, single-stranded, noncoding RNAs that are involved in RNA silencing and post-transcriptional regulation of gene expression. MiRNA can silence mRNA that codes for cancerous proteins, or it can silence miRNA that codes for antitumor proteins. MiRNA-1207-3p can silence the mRNA that codes for FNDC1, a protein that is associated with aggressive prostate cancer. Fibronectin type III domain-containing (FNDC) proteins are an adipokine/myokine family that has many proteins involved in different functions in cells. A handful of the proteins from this family have been directly correlated to proliferation of either aggression or concentration of certain cancer cells. FNDC3 was the chosen protein from this family for visualization. It has been shown that an increase in FNDC3 concentration has been linked to more aggressive prostate cancer. The overexpression of another related protein, FNDC1, has been linked to a resistance in chemotherapy. The purpose of this project is to use visualization to see how mutations in the amino acid sequence of FNDC3 can change its structure, and in the process, change its functionality.
A: Filip Trzcinka Hunter College, City University of New York, A: Oyewole Oyekoya Hunter College, City University of New York, A: Daniel Chan Sarah Lawrence College
A: Cyrus Monteiro Indraprastha Institute of Information Technology, A: Ipsita Rajasekar Indraprastha Institute of Information Technology, A: Prakhar Bhargava Indraprastha Institute of Information Technology, A: Anmol Srivastava Indraprastha Institute of Information Technology
A: Habin Park Hunter College, City University of New York, A: Daniel Lichtman Stockton University, A: Oyewole Oyekoya Hunter College, City University of New York